Prognostic Factors for Survival in Patients With Recurrent Cervical Cancer Previously Treated With Radiotherapy
| Autor: | Seiji Mabuchi, Takayuki Enomoto, Kumiko Temma, Ken-ichirou Morishige, Fumiaki Isohashi, Yasuo Yoshioka, Toshiya Yamamoto, Tadashi Kimura, Takehiro Inoue, Takashi Takeda |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
medicine.medical_specialty Multivariate analysis medicine.medical_treatment Uterine Cervical Neoplasms Models Biological Life Expectancy Internal medicine Humans Medicine In patient Risk factor Survival analysis Retrospective Studies medicine.diagnostic_test business.industry Obstetrics and Gynecology Retrospective cohort study Middle Aged Prognosis Survival Analysis Radiation therapy Positron emission tomography Female Neoplasm Recurrence Local business Chemoradiotherapy |
| Zdroj: | International Journal of Gynecologic Cancer. 20:834-840 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1111/igc.0b013e3181dcadd1 |
| Popis: | Introduction:The aim of this study was to identify the prognostic factors and to establish a model for the prediction of life expectancy in patients with recurrent cervical cancer that had previously been treated with radiotherapy.Methods:The records of consecutive women with recurrent cervical cancer after radiotherapy were retrospectively reviewed. Primary disease, follow-up, and recurrence data were collected. Univariate and multivariate analyses of prognostic factors of survival were performed.Results:A total of 162 patients were included in our database. The median survival after recurrence was 15 months. Multivariate analysis revealed that symptom status, the site of relapse, prior chemoradiotherapy, and treatment modality were significant prognostic factors in terms of survival after recurrence. Patient survival was inversely correlated with the number of these prognostic factors. When the patients were divided into 3 prognostic groups, (low risk: patients with no poor prognostic factors; intermediate: patients with one poor prognostic factor; and high-risk: patients with more than 2 poor prognostic factors), the patients in the high-risk group had a significantly shorter survival (median, 10 months) than those with one risk factor (median, 20 months) or no risk factors (median, 36 months).Conclusions:Symptom status, the site of relapse, prior chemoradiotherapy, and treatment modality are significant prognostic factors in patients with recurrent cervical cancer that had previously been treated with radiotherapy. Our prognostic model, composed of 4 clinical variables, may enable physicians to predict survival more accurately.Abbreviations:CT - Computed tomography, PET-CT - Positron emission tomography in combination with computed tomography, ISBT - Interstitial brachytherapy, DFI - Disease-free interval |
| Databáze: | OpenAIRE |
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