Muscular Dystrophy in a Dog Resembling Human Becker Muscular Dystrophy
| Autor: | Serenella Papparella, I. Esposito, A.B. Baroncelli, B. Peirone, Orlando Paciello, F. Abellonio, Teresa Bruna Pagano |
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| Přispěvatelé: | Baroncelli, Ab, Abellonio, F, Pagano, Tb, Esposito, I, Peirone, B, Papparella, Serenella, Paciello, Orlando |
| Rok vydání: | 2014 |
| Předmět: |
Male
musculoskeletal diseases Muscle tissue congenital hereditary and neonatal diseases and abnormalities Adipose tissue Exercise intolerance Pathology and Forensic Medicine Dystrophin Dogs Animals Medicine Dog Diseases Muscular dystrophy Muscle Skeletal Myopathy Muscle contracture General Veterinary biology business.industry Anatomy Muscular Dystrophy Animal musculoskeletal system medicine.disease Muscular Dystrophy Duchenne medicine.anatomical_structure biology.protein medicine.symptom business ITGA7 |
| Zdroj: | Journal of Comparative Pathology. 150:429-433 |
| ISSN: | 0021-9975 |
| Popis: | A 3-year-old, male Labrador retriever dog was presented with clinical signs of progressive exercise intolerance, bilateral elbow extension, rigidity of the forelimbs, hindlimb flexion and kyphosis. Microscopical examination of muscle tissue showed marked variability in myofibre size, replacement of muscle with mature adipose tissue and degeneration/regeneration of muscle fibres, consistent with muscular dystrophy. Immunohistochemical examination for dystrophin showed markedly reduced labelling with monoclonal antibodies specific for the rod domain and the carboxy-terminal of dystrophin, while expression of β-sarcoglycan, γ-sarcoglycan and β-dystroglycan was normal. Immunoblotting revealed a truncated dystrophin protein of approximately 135 kDa. These findings supported a diagnosis of congenital canine muscular dystrophy resembling Becker muscular dystrophy in man. |
| Databáze: | OpenAIRE |
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