Molecular basis of the little mouse phenotype and implications for cell type-specific growth

Autor:	Paul E. Sawchenko, Michael G. Rosenfeld, Sheng-Cai Lin, Aldons J. Lusis, Ilya Gukovsky, Chijen R. Lin
Rok vydání:	1993
Předmět:	Genetically modified mouse Male Receptors Neuropeptide medicine.medical_specialty Pituitary gland Somatotropic cell medicine.medical_treatment Cellular differentiation DNA Mutational Analysis Molecular Sequence Data Biology Growth Hormone-Releasing Hormone Mice Anterior pituitary Receptors Pituitary Hormone-Regulating Hormone Pituitary Gland Anterior Internal medicine medicine Animals Amino Acid Sequence Dwarfism Pituitary Promoter Regions Genetic Multidisciplinary Binding Sites Base Sequence Cell growth Growth factor Chromosome Mapping Cell Differentiation Phenotype Mice Mutant Strains Cell biology Receptors Neurotransmitter DNA-Binding Proteins Mice Inbred C57BL medicine.anatomical_structure Endocrinology Oligodeoxyribonucleotides Mutation Female Transcription Factor Pit-1 Cell Division Signal Transduction Transcription Factors
Zdroj:	Nature. 364(6434)
ISSN:	0028-0836
Popis:	The molecular basis for the little (lit) mouse phenotype, characterized by a hypoplastic anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary reveals spatially distinct proliferative zones of growth hormone-producing stem cells and mature somatotrophs, each regulated by a different trophic factor. This sequential growth factor requirement for a specific cell type may exemplify a common strategy for regulating cellular proliferation in other mammalian organs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0b6068a32616cd60860e7b070ac75c https://pubmed.ncbi.nlm.nih.gov/8321314 Zobrazit plný text záznamu