Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum
| Autor: | Christian Drosten, Marcel Asper, Boye Weisner, Thomas Grewing, Martin Wilczek, Herbert Schmitz, Petra Emmerich, Stephan Günther, Andreas Roth, Jochen Petersen |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Fever viruses Encephalopathy Molecular Sequence Data Nigeria medicine.disease_cause Polymerase Chain Reaction Virus Pathogenesis Cerebrospinal fluid Lassa Fever Seizures Immunology and Allergy Medicine Humans Amino Acid Sequence Lassa fever Confusion Lassa virus Phylogeny Arenavirus biology Sequence Homology Amino Acid business.industry Reverse Transcriptase Polymerase Chain Reaction virus diseases Middle Aged medicine.disease biology.organism_classification Virology Infectious Diseases RNA Viral Viral disease business Sequence Alignment |
| Zdroj: | The Journal of infectious diseases. 184(3) |
| ISSN: | 0022-1899 |
| Popis: | The pathogenesis of neurologic complications of Lassa fever is poorly understood. A Ni-gerian patient had fever, disorientation, seizures, and blood-brain barrier dysfunction, and Lassa virus was found in cerebrospinal fluid (CSF) but not in serum. The concentration of Lassa virus RNA in CSF corresponded to 1 × 10 3 pfu/mL, as determined by a quantitative real-time polymerase chain reaction assay. To characterize the Lassa virus in CSF, the 3.5-kb S RNA was sequenced. In the S RNA coding sequences, the CSF strain differed between 20% and 24.6% from all known prototype strains. These data suggest that Lassa virus or specific Lassa virus strains can persist in the central nervous system and thus contribute to neuropathogenesis. Lassa virus infection should be considered in West African patients or in travelers returning from this area who present only with fever and neurologic signs. |
| Databáze: | OpenAIRE |
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