Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment

Autor: Mithula Sivasaravanaparan, Jørgen B. Hasselstrøm, Bente Finsen, Elena V. Bouzinova, Ove Wiborg, Louise Ørum Olesen, Maurizio Severino
Předmět:
Male
0301 basic medicine
Aging
Physiology
lcsh:Medicine
Disease
Biochemistry
Open field
Mice
Amyloid beta-Protein Precursor
Mathematical and Statistical Techniques
0302 clinical medicine
Medicine and Health Sciences
Biomechanics
lcsh:Science
Mammals
Principal Component Analysis
Multidisciplinary
Animal Behavior
Neurochemistry
Neurodegenerative Diseases
Animal Models
Neurotransmitters
Paroxetine
Neurology
Animal Sociality
Vertebrates
Physical Sciences
Alzheimer's disease
Statistics (Mathematics)
Research Article
medicine.drug
Biogenic Amines
Serotonin
Elevated plus maze
medicine.medical_specialty
Serotonin reuptake inhibitor
Mouse Models
Mice
Transgenic
Late onset
Research and Analysis Methods
Serotonergic
Rodents
03 medical and health sciences
Model Organisms
Alzheimer Disease
Mental Health and Psychiatry
mental disorders
Presenilin-1
medicine
Animals
Statistical Methods
Maze Learning
Social Behavior
Psychiatry
Behavior
Memory Disorders
Amyloid beta-Peptides
Biological Locomotion
business.industry
lcsh:R
Organisms
Biology and Life Sciences
medicine.disease
Disease Models
Animal
030104 developmental biology
Amniotes
Multivariate Analysis
lcsh:Q
Dementia
Cognition Disorders
business
Zoology
Mathematics
030217 neurology & neurosurgery
Neuroscience
Zdroj: Aarhus University
Olesen, L Ø, Bouzinova, E V, Severino, M, Sivasaravanaparan, M, Hasselstrøm, J B, Finsen, B & Wiborg, O 2016, ' Behavioural phenotyping of APP swe /PS1 δE9 mice : Age-rrelated changes and effect of long-term paroxetine treatment ', PLOS ONE, vol. 11, no. 11, e0165144 . https://doi.org/10.1371/journal.pone.0165144
Olesen, L Ø, Bouzinova, E, Severino, M, Sivasaravanaparan, M, Hasselstrøm, J B, Finsen, B & Wiborg, O 2016, ' Behavioural Phenotyping of APPswe/PS1δE9 Mice: Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment. ', PLOS ONE, vol. 11, no. 11 .
PLoS ONE
Olesen, L Ø, Bouzinova, E V, Severino, M, Sivasaravanaparan, M, Hasselstrøm, J B, Finsen, B & Wiborg, O 2016, ' Behavioural Phenotyping of APPswe/PS1δE9 Mice : Age-Rrelated Changes and Effect of Long-Term Paroxetine Treatment ', PLOS ONE, vol. 11, no. 11, e0165144 . https://doi.org/10.1371/journal.pone.0165144
PLoS ONE, Vol 11, Iss 11, p e0165144 (2016)
DOI: 10.1371/journal.pone.0165144
Popis: Alzheimer's disease (AD) is a devastating illness characterized by a progressive loss of cognitive, social, and emotional functions, including memory impairments and more global cognitive deficits. Clinical-epidemiological evidence suggests that neuropsychiatric symptoms precede the onset of cognitive symptoms both in humans with early and late onset AD. The behavioural profile promoted by the AD pathology is believed to associate with degeneration of the serotonergic system. Using the APPswe/PS1δE9 model of AD-like pathology starting with 9 months old mice, we characterised long term non-cognitive behavioural changes measured at 9, 12, 15, and 18 months of age and applied principal component analysis on data obtained from open field, elevated plus maze, and social interaction tests. Long-term treatment with the selective serotonin reuptake inhibitor (SSRI) paroxetine was applied to assess the role of 5-HT on the behavioural profile; duration of treatment was 9 months, initiated when mice were 9 months of age. Treatment with paroxetine delays the decline in locomotion, in exploration and risk assessment behaviour, found in the APP/PS1 mice. APP/PS1 mice also exhibit low social activity and less aggressiveness, both of which are not affected by treatment with paroxetine. The APP/PS1 behavioural phenotype, demonstrated in this study, only begins to manifest itself from 12 months of age. Our results indicate that treatment with SSRI might ameliorate some of the behavioural deficits found in aged APP/PS1 mice.
Databáze: OpenAIRE
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