Branched-chain amino acid in chronic renal failure patients: Respiratory and sleep effects
| Autor: | Robert I. Lynn, Olli Kirvelä, D.P. Katz, Nancy S. Ginsberg, T. Manner, Jeffrey Askanazi, Eldar Söreide, Björn Skeie |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Sleep Wake Disorders medicine.medical_specialty Respiratory rate Sleep Apnea Syndromes Renal Dialysis Internal medicine Humans Medicine Respiratory system Sleep Stages Sleep disorder business.industry Incidence Respiration Respiratory disease Apnea Sleep apnea Middle Aged medicine.disease Sleep in non-human animals Stimulation Chemical Endocrinology Nephrology Anesthesia Kidney Failure Chronic Female medicine.symptom business Amino Acids Branched-Chain |
| Zdroj: | Kidney International. 40:539-543 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.1991.243 |
| Popis: | Branched-chain amino acid in chronic renal failure patients: Respiratory and sleep effects. Sleep disorders, including a high incidence of sleep apnea, have been recognized as a significant problem in chronic renal failure (CRF) patients. In a preliminary study, we examined CRF patients on maintenance hemodialysis for three nights; one control night, and thereafter randomized to infusion of saline (placebo) for one night and 4% branch-chain amino acid (BCAA) solution for one night. Polysomnographic and respiratory data [respiratory rate, oxygen saturation and end-tidal CO2 (ETCO2)] was recorded continuously throughout the nights and data from each hour compared with baseline (awake) values. The patients studied were characterized by reduced sleep quality and decreased amount of rapid eye movement (REM) sleep. The BCAA infusion was associated with a return of REM sleep to normal and a significant decrease in ETCO2 during both REM and non-REM sleep (P < 0.05). Our findings demonstrate respiratory stimulation during sleep with infusion of BCAA; this stimulatory effect on respiration (in contrast to many respiratory stimulants) is associated with an increased amount of REM sleep. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|