Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries
| Autor: | Marina Vafeiadi, Amrit Kaur Sakhi, Sílvia Fernández-Barrés, Helle Margrete Meltzer, John Wright, Theano Roumeliotaki, Rémy Slama, Sandra Andrusaityte, Cathrine Thomsen, Line Småstuen Haug, Rosemary R. C. McEachan, Xavier Basagaña, Anne Lise Brantsæter, Helle Katrine Knutsen, Leda Chatzi, Regina Grazuleviciene, Léa Maitre, Maribel Casas, Martine Vrijheid, Eleni Papadopoulou |
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| Přispěvatelé: | Institut National de la Santé et de la Recherche Médicale (INSERM), Université Grenoble Alpes (UGA), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire [Grenoble] (CHU)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), European Project, Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
MESH: Dietary Exposure
Health Toxicology and Mutagenesis [SDV]Life Sciences [q-bio] 010501 environmental sciences 01 natural sciences Dietary Exposure MESH: Fluorocarbons 0302 clinical medicine MESH: Pregnancy Pregnancy MESH: Child Halogenated Diphenyl Ethers Hydrocarbons Chlorinated Medicine 030212 general & internal medicine MESH: Maternal Exposure Child 2. Zero hunger MESH: Environmental Pollution Fluorocarbons Likelihood Functions Nutritional status MESH: Metals Heavy Polychlorinated Biphenyls 3. Good health Europe Alkanesulfonic Acids MESH: Environmental Pollutants Maternal Exposure [SDE]Environmental Sciences Environmental Pollutants Female Adult chemistry.chemical_element Food Contamination MESH: Hydrocarbons Chlorinated Arsenic 03 medical and health sciences MESH: Diet Metals Heavy Environmental health MESH: Arsenic Humans MESH: Pesticides Pesticides MESH: Mercury 0105 earth and related environmental sciences MESH: Humans business.industry Extramural MESH: Halogenated Diphenyl Ethers Research Public Health Environmental and Occupational Health MESH: Adult Mercury MESH: Food Contamination medicine.disease Diet Mercury (element) MESH: Polychlorinated Biphenyls Human nutrition chemistry 13. Climate action MESH: Alkanesulfonic Acids MESH: Likelihood Functions [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Europe Environmental Pollution business MESH: Female Food contaminant |
| Zdroj: | Environmental Health Perspectives Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2019, 127 (10), pp.107005. ⟨10.1289/EHP5324⟩ Environmental Health Perspectives, 2019, 127 (10), pp.107005. ⟨10.1289/EHP5324⟩ |
| ISSN: | 0091-6765 1552-9924 |
| DOI: | 10.1289/EHP5324⟩ |
| Popis: | Background: Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. Objectives: Our objective was to study the association between diet and measured blood and urinary levels of environmental contaminants in mother-child pairs from six European birth cohorts (n = 818 mothers and 1,288 children). Methods: We assessed the consumption of seven food groups and the blood levels of organochlorine pesticides, polybrominated diphenyl ethers, polychlorinated biphenyls (PCBs), per- and polyfluoroalkyl substances (PFAS), and heavy metals and urinary levels of phthalate metabolites, phenolic compounds, and organophosphate pesticide (OP) metabolites. Organic food consumption during childhood was also studied. We applied multivariable linear regressions and targeted maximum likelihood based estimation (TMLE). Results: Maternal high (≥ 4times/week) versus low (< 2times/week) fish consumption was associated with 15% higher PCBs [geometric mean (GM) ratio = 1.15; 95% confidence interval (CI): 1.02, 1.29], 42% higher perfluoroundecanoate (PFUnDA) (GMratio = 1.42; 95% CI: 1.20, 1.68), 89% higher mercury (Hg) (GMratio = 1.89; 95% CI: 1.47, 2.41) and a 487% increase in arsenic (As) (GMratio = 4.87; 95% CI: 2.57, 9.23) levels. In children, high (≥ 3times/week) versus low (< 1.5times/week) fish consumption was associated with 23% higher perfluorononanoate (PFNA) (GMratio = 1.23; 95% CI: 1.08, 1.40), 36% higher PFUnDA (GMratio = 1.36; 95% CI: 1.12, 1.64), 37% higher perfluorooctane sulfonate (PFOS) (GMratio = 1.37; 95% CI: 1.22, 1.54), and >200% higher Hg and As [GMratio = 3.87 (95% CI: 1.91, 4.31) and GMratio = 2.68 (95% CI: 2.23, 3.21)] concentrations. Using TMLE analysis, we estimated that fish consumption within the recommended 2-3 times/week resulted in lower PFAS, Hg, and As compared with higher consumption. Fruit consumption was positively associated with OP metabolites. Organic food consumption was negatively associated with OP metabolites. Discussion: Fish consumption is related to higher PFAS, Hg, and As exposures. In addition, fruit consumption is a source of exposure to OPs. https://doi.org/10.1289/EHP5324. The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreement no. 308,333, the Human Early Life Exposome (HELIX) project. The Environment and Childhood (INMA) Sabadell cohort and biomarker measurements were funded by grants from Instituto de Salud Carlos III [Red INMA G03/176; CB06/02/0041; PI041436; PI081151 including Federación Española de Enfermedades Raras (FEDER) funds; PI12/01,890 including FEDER funds; CP13/00,054 including FEDER funds], CIBERESP, Generalitat de Catalunya-Consell Interdepartamental de Recerca i Innovació Tecnològica (CIRIT) 1999SGR 00,241, Generalitat de Catalunya-Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090,430), Spanish Ministry of Economy and Competitiveness (SAF2012-32,991 including FEDER funds). The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, National Institutes of Health, National Institute of Neurological Disorders and Stroke (NIH/NINDS; grants UO1 NS 047,537-01 and UO1 NS 047,537-06A1). The Rhea cohort was financially supported by European projects [EU FP6-2003-Food-3-NewGeneris, EU FP6 STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. (project no. 211,250 Escape), EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009-single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. (proposal no. 226,285 ENRIECO), EU- FP7-HEALTH-2012 (proposal no. 308,333 HELIX)] and by the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, in Heraklion District, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15). The Lithuanian Kaunas Cohort (KANC) supported by the Lithuanian Agency for Science Innovation and Technology (No. 31V-77). M.C. received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00,128). E.P. and A.L.B. received funding from the Norwegian Research Council (Project No. 268,465). R.R.C.M. and J.W. were supported by the National Institute for Health Research (NIHR) Collaborations for Leadership in Applied Health Research and Care (CLAHRC) Yorkshire and Humber (IS-CLA-0113-10,020; http://www.clahrc-yh.nihr.ac.uk). L.C. received funding from the NIH (P30ES007048) and National Institute of Environmental Health Sciences (NIEHS R21ES02890). |
| Databáze: | OpenAIRE |
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