Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression
| Autor: | Martin Walter, Chun-Hong Liu, Meng Li, Ming-Hao Yang, Bin Li, Xiao-Xu Wang, Guang-Zhong Zhang, Lihong Wang, Marie Woelfer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Anti-inflammation Depression Transcutaneous auricular vagus nerve stimulation Vagus nerve Brain network Neurology Vagus Nerve Stimulation medicine.medical_treatment Immunology Review lcsh:RC346-429 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine medicine Biological neural network Acupuncture Humans Prefrontal cortex Default mode network lcsh:Neurology. Diseases of the nervous system Depressive Disorder business.industry General Neuroscience Brain medicine.disease 030104 developmental biology Major depressive disorder Nerve Net business Neuroscience 030217 neurology & neurosurgery Vagus nerve stimulation |
| Zdroj: | Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-11 (2020) Journal of Neuroinflammation Journal of neuroinflammation, 17(1):54 |
| ISSN: | 1742-2094 |
| Popis: | Transcutaneous auricular vagus nerve stimulation (taVNS) is a relatively non-invasive alternative treatment for patients suffering from major depressive disorder (MDD). It has been postulated that acupuncture may achieve its treatment effects on MDD through suppression of vagal nerve inflammatory responses. Our previous research established that taVNS significantly increases amygdala–dorsolateral prefrontal cortex connectivity, which is associated with a reduction in depression severity. However, the relationship between taVNS and the central/peripheral functional state of the immune system, as well as changes in brain neural circuits, have not as yet been elucidated. In the present paper, we outline the anatomic foundation of taVNS and emphasize that it significantly modulates the activity and connectivity of a wide range of neural networks, including the default mode network, executive network, and networks involved in emotional and reward circuits. In addition, we present the inflammatory mechanism of MDD and describe how taVNS inhibits central and peripheral inflammation, which is possibly related to the effectiveness of taVNS in reducing depression severity. Our review suggests a link between the suppression of inflammation and changes in brain regions/circuits post taVNS. |
| Databáze: | OpenAIRE |
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