The pattern of estradiol and progesterone differs in serum and tissue of benign and malignant ovarian tumors
| Autor: | Torbjörn Bäckström, Peter Lindgren, Jan I. Olofsson, Stefan Cajander, Mats-Göran Damber, D. Zhu, C.-G. Mählck |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
endocrine system
Cancer Research medicine.medical_specialty endocrine system diseases medicine.drug_class Cancer Ovary Biology medicine.disease female genital diseases and pregnancy complications Ovarian tumor medicine.anatomical_structure Endocrinology Oncology Estrogen Internal medicine medicine Cyst Ovarian cancer Hormone Ovarian vein |
| Zdroj: | Karolinska Institutet Scopus-Elsevier |
| ISSN: | 1791-2423 1019-6439 |
| Popis: | Epidemiological studies have indicated a relationship between gonadal steroid hormones and ovarian cancer. A production of both estradiol and progesterone by ovarian cancers has been demonstrated. The local steroid concentrations and the putative relation to histopathological and clinical condition were investigated herein. Ovarian tissue, ovarian tumor cyst fluid, ovarian vein samples and peripheral serum concentrations of estradiol and progesterone in pre- and post-menopausal women, subdivided into groups with normal ovaries, benign, borderline and malignant ovarian tumors, were quantitatively assessed. Both ovarian tissue concentrations of estradiol and progesterone were more than 100-fold higher than in serum. Based on differences in concentrations between different ovarian tumor groups, the data is not coherent with the previously suggested increased production of estradiol and progesterone in ovarian cancer tissue, since post-menopausal women with ovarian cancer presented lower median tissue hormone levels, most pronounced between malignant and benign tumors; median (25 and 75 percentile) estradiol; 9.40 (6.67-15.50) vs 16.44 (12.49-23.20), p=0.02 and progesterone; 308 (240-575) vs 957 (553-1143) pmol/g wet weight, p |
| Databáze: | OpenAIRE |
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