Low-carbohydrate high-protein diet diminishes the insulin response to glucose load via suppression of SGLT-1 in mice
| Autor: | Sachika Inoue, Xi Li, Saki Kitai, Naoya Nakai, Noriko Iida, Kazuhiko Higashida, Shin Terada |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty 030209 endocrinology & metabolism Carbohydrate metabolism Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry 03 medical and health sciences Sodium-Glucose Transporter 1 0302 clinical medicine Internal medicine Intestine Small Insulin response medicine Animals Insulin Muscle Skeletal Molecular Biology 030109 nutrition & dietetics Chemistry Organic Chemistry Glucose transporter Insulin sensitivity General Medicine Glucose Tolerance Test Mice Inbred C57BL Glucose Endocrinology Low protein high carbohydrate Insulin Resistance Diet High-Protein Low-Carbohydrate Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 83:365-371 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1080/09168451.2018.1533803 |
| Popis: | The purpose of this study was to examine the effects of a low-carbohydrate high-protein (LCHP) diet on the expression of glucose transporters and their relationships to glucose metabolism. Male C57BL/6 mice were fed a normal control or LCHP diet for 2 weeks. An oral glucose tolerance test and insulin tolerance test (ITT) were performed, and the expression of glucose transporters was determined in the gastrocnemius muscle, jejunum and pancreas. The increase in plasma insulin concentrations after glucose administration was reduced in the LCHP group. However, LCHP diet had no effects on peripheral insulin sensitivity or glucose transporters expression in the gastrocnemius and pancreas. Soluble glucose transporter (SGLT)-1 protein content in jejunum was lower in the LCHP group. Taken together, these results suggest that the blunted insulin response after glucose administration in LCHP diet-fed mice might be due to decreased SGLT-1 expression, but not to an increase in peripheral insulin sensitivity. Abbreviations: LCHP: low-carbohydrate high-protein; ITT: insulin tolerance test; GLUT: glucose transporter; SGLT: soluble glucose transporter; OGTT: oral glucose tolerance test; AUC: area under the curve. |
| Databáze: | OpenAIRE |
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