Clinical Studies of COMET for Total LSCD: a Review of the Methods and Molecular Markers for Follow-Up Characterizations
| Autor: | Graziella Pellegrini, Giulia Galaverni, Eustachio Attico |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Conjunctiva business.industry Tissue characterization Bioinformatics Transplantation Clinical trial 03 medical and health sciences Ophthalmology 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Molecular level Cornea Oral mucosa Cornea Cultivated oral mucosa epithelial cell transplantation (COMET) Cultivated autologous oral mucosal epithelial cell sheet (CAOMECS) Total bilateral limbal stem cell deficiency (LSCD) Biomarkers 030221 ophthalmology & optometry medicine sense organs Oral mucosa business |
| Zdroj: | Current Ophthalmology Reports. 9:25-37 |
| ISSN: | 2167-4868 |
| DOI: | 10.1007/s40135-020-00263-9 |
| Popis: | This review outlines the main features of the clinical trials where cultivated oral mucosa epithelial cell transplantation (COMET) was performed, aiming to underscore a link between the clinical outcome and the expression of specific markers during the follow-up of patients, characteristic for a defined epithelium (cornea, oral mucosa, or conjunctiva) or related to vascularization. Currently, little is known about the reasons underlying the success or failure of COMET. To address this issue, we focused on tissue characterization at the molecular level, highlighting the findings concerning angiogenesis. There are several discrepancies in the outcomes of COMET clinical trials. While some corneal/conjunctival markers can be considered reliable for understanding the biological mechanisms that drive corneal repair after transplants, a unique marker specifically expressed in the oral mucosa and an accurate study of the vascularization processes are currently missing. Together, these insights will help forecast successes and failures of these technologies. |
| Databáze: | OpenAIRE |
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