Total Synthesis and Determination of the Absolute Configuration of Rakicidin C

Autor:	Liang Wang, Yue Chen, Fangzhi Han, Guangju Liu, Chaofan Jin, Wang Jinghan, Jianwei Liu
Rok vydání:	2021
Předmět:	Chemistry Yield (chemistry) Organic Chemistry Analytical chemistry Absolute configuration Total synthesis Physical and Theoretical Chemistry Optical rotation Biochemistry
Zdroj:	Organic letters. 23(18)
ISSN:	1523-7052
Popis:	The absolute configuration of rakicidin C was predicted by comparison of optical rotation data and absolute configuration of APD-cyclic depsipeptides and further determined by total synthesis. The absolute configuration of five chiral centers was determined as 2R, 15R, 16R, 17S, and 19S. Our efficient route involves 19 longest linear steps with an overall yield of 1.49%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9f7ec0867fa9471c0f56ca2302865a https://pubmed.ncbi.nlm.nih.gov/34459614 Zobrazit plný text záznamu