Mechanisms of Antibacterial Activity of MgO: Non-ROS Mediated Toxicity of MgO Nanoparticles TowardsEscherichia coli
| Autor: | Zhiyong Shen, David Lee Phillips, Yip Hang Ng, Wai Kin Chan, Patrick K. H. Lee, Frederick C. Leung, Xiaoying Xu, Li Hong Yu, Alan Man Ching Ng, Charis M.N. Chan, Lee A. Gethings, Angel P. Y. Ma, Mu Yao Guo, Aleksandra B. Djurišić, Yu Hang Leung, Mabel Ting Wong |
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| Rok vydání: | 2013 |
| Předmět: |
Lipopolysaccharides
Time Factors Materials science Ultraviolet Rays Inorganic chemistry Microbial Sensitivity Tests medicine.disease_cause Nanomaterials Biomaterials Cell membrane Lipid peroxidation chemistry.chemical_compound Spectroscopy Fourier Transform Infrared Escherichia coli medicine General Materials Science Particle Size chemistry.chemical_classification Reactive oxygen species Electron Spin Resonance Spectroscopy Membrane Proteins General Chemistry Anti-Bacterial Agents Gene Ontology medicine.anatomical_structure chemistry Toxicity Biophysics Nanoparticles Magnesium Oxide Reactive Oxygen Species Antibacterial activity Metabolic Networks and Pathways Oxidative stress Biotechnology |
| Zdroj: | Small. 10:1171-1183 |
| ISSN: | 1613-6810 |
| Popis: | The toxicity of metal oxide nanomaterials and their antimicrobial activity is attracting increasing attention. Among these materials, MgO is particularly interesting as a low cost, environmentally-friendly material. The toxicity of MgO, similar to other metal oxide nanomaterials, is commonly attributed to the production of reactive oxygen species (ROS). We investigated the toxicity of three different MgO nanoparticle samples, and clearly demonstrated robust toxicity towards Escherichia coli bacterial cells in the absence of ROS production for two MgO nanoparticle samples. Proteomics data also clearly demonstrate the absence of oxidative stress and indicate that the primary mechanism of cell death is related to the cell membrane damage, which does not appear to be due to lipid peroxidation. |
| Databáze: | OpenAIRE |
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