‘Auto’-immune neutropenia after allogeneic bone marrow transplantation unresponsive to conventional immunosuppression but resolving promptly after splenectomy
| Autor: | H. Koeppler, John M. Goldman |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Neutropenia medicine.medical_treatment Splenectomy medicine Humans Transplantation Homologous Bone Marrow Transplantation Autoimmune disease business.industry Immunosuppression Hematology General Medicine medicine.disease medicine.anatomical_structure Immunology Prednisolone Absolute neutrophil count Plasmapheresis Bone marrow business Agranulocytosis medicine.drug |
| Zdroj: | European Journal of Haematology. 41:182-185 |
| ISSN: | 1600-0609 0902-4441 |
| DOI: | 10.1111/j.1600-0609.1988.tb00889.x |
| Popis: | A 32-year-old male presented with isolated neutropenia 6 months after allogeneic bone marrow transplantation for CML from his HLA-matched brother. The presence of granulocyte-specific IgM and IgG antibodies in the patient's serum indicated an immune-mediated basis for the neutropenia. A variety of manoeuvres to suppress antibody production or to reduce peripheral destruction, including high-dose intravenous immunoglobulins 400 mg/kg (total 24 g) on 5 consecutive days, prednisolone 80 mg for 10 d and plasmapheresis on 3 consecutive d, failed to raise the neutrophil count. Splenectomy, however, resulted in a prompt and sustained rise of neutrophils to normal values. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text