Effect of nitrofurans and NO generators on biofilm formation by Pseudomonas aeruginosa PAO1 and Burkholderia cenocepacia 370
| Autor: | Julia Zaitseva, I. A. Khmel, V. G. Granik, Olga A. Koksharova, Alexei A. Belik |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
biology
Burkholderia cenocepacia Nitrofurans Pseudomonas aeruginosa medicine.drug_class Burkholderia cepacia complex Biofilm General Medicine biochemical phenomena metabolism and nutrition Nitric Oxide biology.organism_classification medicine.disease_cause Microbiology Anti-Bacterial Agents Burkholderia Biofilms medicine Molecular Biology Nitrofuran Pseudomonadaceae Nifuroxazide medicine.drug |
| Zdroj: | Research in Microbiology. 160:353-357 |
| ISSN: | 0923-2508 |
| Popis: | Antibacterial drugs in the nitrofuran series, such as nitrofurazone, furazidin, nitrofurantoin and nifuroxazide, as well as the nitric oxide generators sodium nitroprusside and isosorbide mononitrate in concentrations that do not suppress bacterial growth, were shown to increase the capacity of pathogenic bacteria Pseudomonas aeruginosa PAO1 and Burkholderia cenocepacia 370 to form biofilms. At 25-100microg/ml, nitrofurans 2-2.5-fold enhanced biofilm formation of P. aeruginosa PAO1, and NO donors 3-6-fold. For B. cenocepacia 370, the enhancement was 2-5-fold (nitrofurans) and 4.5-fold (sodium nitroprusside), respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect