Extracellular Vesicles: A New Perspective in Tumor Therapy
| Autor: | Zong-Sheng Jiang, Junshan Ruan, Ling Wang, Yan-Zi Sun, Shao-Ming Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Epithelial-Mesenchymal Transition lcsh:Medicine Antineoplastic Agents Endogeny Review Article medicine.disease_cause Extracellular vesicles General Biochemistry Genetics and Molecular Biology Metastasis Extracellular Vesicles 03 medical and health sciences Drug Delivery Systems Neoplasms Tumor Microenvironment medicine Humans Epithelial–mesenchymal transition Tumor microenvironment General Immunology and Microbiology Chemistry Cell growth lcsh:R Cancer General Medicine medicine.disease Cell Transformation Neoplastic 030104 developmental biology Cancer research Carcinogenesis |
| Zdroj: | BioMed Research International, Vol 2018 (2018) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | In recent years, the study of extracellular vesicles has been booming across various industries. Extracellular vesicles are considered one of the most important physiological endogenous carriers for the specific delivery of molecular information (nucleonic acid, cytokines, enzymes, etc.) between cells. It has been discovered that they perform a critical role in promoting tumor cell growth, proliferation, tumor cell invasion, and metastatic ability and regulating the tumor microenvironment to promote tumor cell communication and metastasis. In this review, we will discuss (1) the mechanism of extracellular vesicles generation, (2) their role in tumorigenesis and cancer progression (cell growth and proliferation, tumor microenvironment, epithelial-mesenchymal transition (EMT), invasion, and metastasis), (3) the role of extracellular vesicles in immune therapy, (4) extracellular vesicles targeting in tumor therapy, and (5) the role of extracellular vesicles as biomarkers. It is our hope that better knowledge and understanding of the extracellular vesicles will offer a wider range of effective therapeutic targets for experimental tumor research. |
| Databáze: | OpenAIRE |
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