| Autor: |
Mariana Alejandra Machuca, Francisco Hernandez, Esther Ramos, Rodrigo Papa-Gobbi, María Virginia Gentilini, Alba Bueno, J Serradilla, Martín Rumbo, Pablo Klin, Manuel López-Santamaría, María Elena Vela, Alida Alcolea, Nidia M. Arreola, Gerardo Prieto, Pablo Stringa, Antonio Pérez-Martínez, Gabriel Gondolesi, Ane Andres |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Annals of surgery. |
| ISSN: |
1528-1140 |
| Popis: |
OBJECTIVE We aimed to assess whether native spleen preservation during VT affects GVHD incidence. SUMMARY BACKGROUND DATA Graft-versus-host-disease (GVHD) is one of the most severe and frequently lethal hematological complications after visceral transplantation (VT) procedures. Because there is no specific treatment for GVHD, it is imperative to develop a strategy to reduce donor lymphocyte engraftment and proliferation. METHODS Our study included both clinical and experimental data. A total of 108 patients were divided into three groups: a native spleen preservation group, a native spleen removal with no donor spleen group, and a donor spleen included (allogeneic spleen) group. We also used an allogeneic VT rat model, in which recipients were divided into two groups: a native spleen preservation (+SP) group and a native spleen removal (-S) group. Skin rash appearance, histopathological changes, chimerism, and spleen effects on circulating allogeneic T-cells were assessed. RESULTS The patients with native spleen preservation showed a lower rate of GVHD (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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