Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure
| Autor: | John D. Elsworth, Jane R. Taylor, Robert H. Roth, Peter Jatlow, Brian A. Horger |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Metabolite Pharmacology Locomotor activity Sensitivity and Specificity Rats Sprague-Dawley chemistry.chemical_compound Cocaethylene Cocaine Dopamine Uptake Inhibitors medicine Animals Drug Interactions Molecular Biology Sensitization Chromatography High Pressure Liquid Analysis of Variance Behavior Animal business.industry General Neuroscience Bioavailability Rats Neostriatum medicine.anatomical_structure chemistry Neurology (clinical) business Locomotion Developmental Biology medicine.drug |
| Zdroj: | Brain research. 733(1) |
| ISSN: | 0006-8993 |
| Popis: | The present study assessed the ability of cocaethylene to induce sensitization to the behavioral activating effects of cocaine in the male Sprague-Dawley rat. Preexposure to cocaethylene (15 or 25 mg/kg) significantly enhanced the locomotor activating effects of a subsequent cocaine (15 mg/kg) challenge injection. In addition, acute intraperitonecal administration at several doses (10, 15, or 25 mg/kg) confirmed previous reports of increased bioavailability of cocaine in brain and plasma relative to cocaethylene. These data are discussed in terms of previous work in which a significant augmentation of cocaine-induced locomotor activity was not observed following cocaethylene preexposure. |
| Databáze: | OpenAIRE |
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