Hydrogen sulfide in ageing, longevity and disease
| Autor: | Stephen E. Wilkie, Colin Selman, Nicholas M. Morton, Roderick N. Carter, Gillian Borland |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
gasotransmitters
Aging Natural resource economics media_common.quotation_subject Hydrogen sulfide Longevity hydrogen sulfide Context (language use) Disease Biochemistry Molecular Bases of Health & Disease chemistry.chemical_compound Ischemia Metalloproteins Animals Humans Molecular Biology Review Articles media_common Post-Translational Modifications Geroscience geroscience progeria Extremities Cell Biology Toxic gas equipment and supplies Signaling Metabolism chemistry Ageing Osteoporosis Business Protein Processing Post-Translational Signal Transduction |
| Zdroj: | Biochemical Journal |
| ISSN: | 0264-6021 |
| Popis: | Hydrogen sulfide (H2S) modulates many biological processes, including ageing. Initially considered a hazardous toxic gas, it is now recognised that H2S is produced endogenously across taxa and is a key mediator of processes that promote longevity and improve late-life health. In this review, we consider the key developments in our understanding of this gaseous signalling molecule in the context of health and disease, discuss potential mechanisms through which H2S can influence processes central to ageing and highlight the emergence of novel H2S-based therapeutics. We also consider the major challenges that may potentially hinder the development of such therapies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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