Estimates of population-based incidence of malignant arrhythmias associated with medication use-a narrative review
| Autor: | Mhd Wasem Alsabbagh, Yichang Huang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Canada Databases Factual Drug-Related Side Effects and Adverse Reactions Population Torsades de pointes 030226 pharmacology & pharmacy Risk Assessment 03 medical and health sciences 0302 clinical medicine Heart Conduction System Heart Rate Risk Factors Torsades de Pointes Epidemiology medicine Humans Pharmacology (medical) Medical prescription Intensive care medicine education Pharmacology Estimation education.field_of_study business.industry Incidence (epidemiology) Incidence Pharmacoepidemiology medicine.disease Long QT Syndrome business 030217 neurology & neurosurgery Adverse drug reaction |
| Zdroj: | Fundamentalclinical pharmacologyREFERENCES. 34(4) |
| ISSN: | 1472-8206 |
| Popis: | Certain medications are reported to be associated with acquired long-QT syndrome (ALQTS), which can degenerate into a potentially severe 'malignant' arrhythmia known as torsades de pointes (TdP). However, population-based estimations of the incidence of medication-associated malignant arrhythmia are limited. The purpose of this article is to review the clinical symptoms, cellular mechanism, categorization, and risk factors of these malignant arrhythmias, as well as illustrate results and methodological limitations of epidemiological literature which have previously estimated population-based incidence of ALQTS and malignant arrhythmia. Administrative databases in universal healthcare systems (such as Canada) can be used to provide a robust estimate of this incidence. We present a valid operational definition of medication-associated malignant arrhythmia, using Canadian hospital administrative data linked to prescription databases that can be used to estimate the population-based incidence. An estimation of incidence may have important implications with regard to understanding the potential widespread distribution of this adverse effect-which may influence medication prescribing patterns. |
| Databáze: | OpenAIRE |
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