Cancers in patients with hemophilia: a retrospective study from the Italian Association of Hemophilia Centers
| Autor: | Tagliaferri, A, Di Perna, C, Santoro, Cristina, Schinco, P, Santoro, R, Rossetti, G, Coppola, A, Morfini, M, Franchini, M, Italian Association of Hemophilia Centers, Mazzucconi, Maria Gabriella, Castaman, G, Scaraggi, Fa, Macchi, S, Pasca, S, Valdrè, L, Zanon, E, Radossi, P, Serino, Ml, Cantori, I, Napolitano, M, Lapecorella, M, Giuffrida, Ac, Dragani, A, Delios, G, Arbasi, M. C. |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pediatrics standardized mortality ratio Hepatitis C virus Population HIV Infections Comorbidity Therapeutics medicine.disease_cause Hemophilia A Neoplasms hemophilia Epidemiology medicine Humans cancer education Retrospective Studies education.field_of_study therapy business.industry Cancer Retrospective cohort study Hemophilia Mortality Standardized mortality ratio Therapy Hepatitis C Italy Hematology medicine.disease cancer hemophilia mortality standardized mortality ratio therapy mortality Surgery business |
| Popis: | Summary. Background: The increased life expectancy of the hemophilia population, primarily as a result of advances in factor replacement therapy, has enabled hemophiliacs to reach an older age. Consequently, age-related diseases, such as cardiovascular disorders and cancers, are being increasingly recognized in such patients. However, only few data are available on such co-morbidities, their management and impact on the primary bleeding disorders. Objectives: With the aim of investigating several still unclear issues regarding cancers in hemophilia patients, we conducted, on behalf the Italian Association of Hemophilia Centers (AICE), a study on cancers among Italian hemophiliacs. Patients: Data pertaining to 122 hemophiliacs with 127 cancers between 1980 and 2010 were retrospectively collected in 21 centers of the AICE which chose to participate. Results: Sixty-nine percent of cancers were recorded during the decade 2001–2010. Eighty-three percent of patients were infected with hepatitis C virus (HCV) and 22% of them were also co-infected with human immunodeficiency virus (HIV). Forty-three percent of cancers were HCV-related, whereas 9% were HIVrelated. Virus-related cancers were more frequent and non-virus-related cancers less frequent in patients with severe hemophilia than in those with mild/moderate forms (P = 0.0004). The non-virus-related standardized mortality ratio (SMR) was 0.3. Hemorrhagic complications occurred more frequently in patients undergoing chemotherapy (14%) or radiotherapy (19%). Conclusions: The results of the present study confirm that cancers have become a new challenge for physicians working in hemophilia centers and underline the need for prospective trials to better assess the epidemiology and to optimize the management of hemophiliacs with cancer. |
| Databáze: | OpenAIRE |
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