Significance of estrogen and progesterone receptors, disease-free interval, and site of first metastasis on survival of breast cancer patients
| Autor: | Esa-Matti Tolppanen, Arto Alanko, Erkki Heinonen, Reijo Vihko, Theodor M. Scheinin |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Time Factors medicine.drug_class medicine.medical_treatment Mammary gland Breast Neoplasms Metastasis Breast cancer Internal medicine medicine Endocrine system Humans Nandrolone Neoplasm Metastasis Receptor Mastectomy Disease free interval business.industry medicine.disease Tamoxifen medicine.anatomical_structure Endocrinology Receptors Estrogen Estrogen Nandrolone Decanoate Female business Receptors Progesterone |
| Zdroj: | Cancer. 56(7) |
| ISSN: | 0008-543X |
| Popis: | Estrogen and progesterone receptors (ER/PR) were measured in primary tumors and metastases of 397 breast cancer patients. Survival following mastectomy was significantly longer in patients with ER and PR positive tumors, as was survival after first recurrence. The prognostic value of ER and PR was compared with such clinical factors as disease-free interval (DFI) and the dominant site of first metastasis by Cox's regression analysis. With all the different therapy modalities long DFI was the best prognostic indicator. However, in the patient group treated with endocrine therapy, ER and PR positivity was the best prognostic indicator, suggesting that longer survival in receptor positive patients was related to the response to endocrine treatment. |
| Databáze: | OpenAIRE |
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