Clinical experience with adjunctive perampanel in adult patients with uncontrolled epilepsy: A UK and Ireland multicentre study
| Autor: | Steven Kemp, Emily Jane Shah, Peter Goulding, Norman Delanty, Markus Reuber, Cora Flynn |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Efficacy Pyridones Sedation Population Clinical Neurology Perampanel Young Adult 03 medical and health sciences chemistry.chemical_compound Epilepsy 0302 clinical medicine Responder rate Nitriles Humans Medicine 030212 general & internal medicine Adverse effect education Aged Retrospective Studies education.field_of_study business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease Tolerability United Kingdom chemistry Neurology Anesthesia Adjunctive treatment Anticonvulsants Drug Therapy Combination Female Neurology (clinical) medicine.symptom business Ireland 030217 neurology & neurosurgery Antiepileptic drug |
| Zdroj: | Seizure. 34:1-5 |
| ISSN: | 1059-1311 |
| DOI: | 10.1016/j.seizure.2015.10.017 |
| Popis: | Purpose To derive clinically useful information about the efficacy and tolerability of adjunctive treatment with perampanel for refractory epilepsy in an outpatient setting. Method We pooled retrospective casenotes data of adult patients with refractory epilepsy prescribed perampanel from 18 hospitals throughout UK and Ireland. Results Three hundred and ten patients were included (mean age 40.9 [SD=12.0], 50% women, 27.7% with learning disability). The mean duration of epilepsy was 26.7 years (range 2–67 years, SD=13.5) and 91.9% were taking two or more anti-epileptic drugs at the time of perampanel initiation. Mean retention was 6.9 months (range 1 day–22.3 months, SD=4.5). The retention was 86% at 3 months, 71% at 6 months, 47.6% at 12 months and 27% at 18 months. At final follow-up a >50% reduction in seizure frequency was reached in 57.5% of tonic–clonic seizures, 57.4% of complex partial seizures and 43.8% of simple partial seizures. Eleven patients (3.5%) became seizure free. Two hundred and nine patients (67.4%) experienced adverse effects and of these 67% withdrew treatment due to their effects. The most common were sedation, behaviour/mood disturbance, dizziness, and unsteadiness. Conclusion Perampanel appears a safe and effective antiepileptic drug when used as adjunctive therapy in patients with uncontrolled partial epilepsy (including those with learning disability), although few patients achieved complete seizure control. Long-term retention was slightly lower than reported rates for other anti-epileptic drugs, potentially due to the highly refractory population. Monitoring for adverse effects on energy levels, mood and behaviour is recommended. |
| Databáze: | OpenAIRE |
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