Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans
| Autor: | Tanya J Major, Jaimon T Kelly, Robert MacGinley, Alwyn S Todd, Richard J. Johnson, Tony R. Merriman, Robert J. Walker |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Original Contributions Sodium chemistry.chemical_element Blood Pressure 030204 cardiovascular system & hematology Renin-Angiotensin System 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Renin Renin–angiotensin system Internal Medicine medicine Humans 030212 general & internal medicine Hyperuricemia Aldosterone Aged business.industry Sodium Dietary Diet Sodium-Restricted Middle Aged medicine.disease Diet Uric Acid Clinical trial Blood pressure Endocrinology chemistry Hypertension Uric acid Female business Low sodium |
| Zdroj: | American Journal of Hypertension. 30:1196-1202 |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1093/ajh/hpx123 |
| Popis: | Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, moderating or contributing factor to the development of hypertension has not been fully evaluated and very few studies have reported interactions between sodium intake and serum uric acid. We performed further analysis of our randomized controlled clinical trials (Australian New Zealand Clinical Trials Registry #12609000161224 and #12609000292279) designed to assess the effects of modifying sodium intake on concentrations of serum markers, including uric acid. Uric acid and other variables (including blood pressure, renin, and aldosterone) were measured at baseline and 4 weeks following the commencement of low (60 mmol/day), moderate (150 mmol/day), and high (200-250 mmol/day) dietary sodium intake. The median aldosterone-to-renin ratio was 1.90 [pg/ml]/[pg/ml] (range 0.10-11.04). Serum uric acid fell significantly in both the moderate and high interventions compared to the low sodium intervention. This pattern of response occurred when all subjects were analyzed, and when normotensive or hypertensive subjects were analyzed alone. Although previously reported in hypertensive subjects, these data provide evidence in normotensive subjects of an interaction between dietary sodium intake and serum uric acid. As this interaction is present in the absence of hypertension, it is possible it could play a role in hypertension development, and will need to be considered in future trials of dietary sodium intake. The trials were registered with the Australian and New Zealand Clinical Trials Registry as ACTRN12609000161224 and ACTRN1260. |
| Databáze: | OpenAIRE |
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