Lung cancer risk in past asbestos workers a few decades after exposure cessation and prospects for screening

Autor:	Emanuela Fadda, Maria Nicoletta Ballarin, L Marchiori, Ugo Fedeli, Giuseppe Mastrangelo, G Marangi, Flavio Valentini, Luca Scoizzato
Rok vydání:	2016
Předmět:	Adult Male Lung Neoplasms Time Factors Health Toxicology and Mutagenesis Asbestosis Population Toxicology medicine.disease_cause Risk Assessment Asbestos Cohort Studies 03 medical and health sciences symbols.namesake 0302 clinical medicine Occupational Exposure Environmental health Humans Mass Screening Medicine Poisson Distribution Poisson regression Lung cancer education Mass screening Aged General Environmental Science Aged 80 and over education.field_of_study business.industry Public Health Environmental and Occupational Health Middle Aged medicine.disease 030210 environmental & occupational health respiratory tract diseases Occupational Diseases Italy 030220 oncology & carcinogenesis symbols Medical emergency business Risk assessment Lung cancer screening
Zdroj:	Archives of Environmental & Occupational Health. 71:237-244
ISSN:	2154-4700 1933-8244
Popis:	To ascertain whether the current risk of lung cancer in former asbestos workers was higher than in the general population, 1,557 past asbestos workers were recruited during statutory health examinations (from 2000 onward) and followed up for mortality. Standardized mortality ratios (SMRs) were calculated. Poisson regression was used to adjust the rate ratios (RRs) for confounders. SMR was about 1.00 in workers with or without pleural plaques and 4.62 (95% confidence interval: 0.61-18.1) in those with asbestosis. Adjusted RRs for lung cancer were 4.70 (0.99-22.5) for asbestosis, 4.35 (0.97-19.5) for former smokers, 6.82 (1.38-34.4) for current smokers. Currently, lung cancer mortality in past asbestos workers is similar to the general population, probably because workers more exposed /more susceptible could have died from lung cancer before the beginning of follow-up.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd80eba4fd96d9cbfb363904e3d4d31c https://doi.org/10.1080/19338244.2015.1134423 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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