Pre-operative Obesity-Associated Hyperandrogenemia in Women and Hypogonadism in Men Have No Impact on Weight Loss Following Bariatric Surgery
| Autor: | Gerhard Prager, Michael Krebs, Tamara Ranzenberger-Haider, Paul Fellinger, Alexandra Kautzky-Willer, Hannes Beiglböck, Bianca K. Itariu, Peter Wolf |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Original Contributions Bariatric Surgery 030209 endocrinology & metabolism Androgen Excess Androgen excess Body Mass Index 03 medical and health sciences 0302 clinical medicine Weight loss Weight Loss Medicine Testosterone deficiency Humans Testosterone Obesity Retrospective Studies 030219 obstetrics & reproductive medicine Nutrition and Dietetics business.industry Hypogonadism Lipid metabolism Anthropometry Androgen medicine.disease Surgery Obesity Morbid Functional hypogonadism Female medicine.symptom business Body mass index Hormone |
| Zdroj: | Obesity Surgery |
| ISSN: | 1708-0428 0960-8923 |
| Popis: | Background In severe obesity, hypogonadism in men and androgen excess in women are frequently observed. Sex hormones play an important role in body composition and glucose and lipid metabolism. However, whether pre-operative gonadal dysfunction impacts weight loss after bariatric surgery is not fully known. Methods A total of 49 men and 104 women were included in a retrospective analysis. Anthropometric characteristics, glucose and lipid metabolism, and androgen concentrations were assessed pre-operatively and 17.9 ± 11 or 19.3 ± 12 months post-operatively in men and women. Men with (HYPOmale) and without (controls: CONmale) pre-operative hypogonadism, as well as women with (HYPERfemale) and without (controls: CONfemale) pre-operative hyperandrogenemia, were compared. Results In men, pre-operative hypogonadism was present in 55% and linked to a higher body mass index (BMI): HYPOmale 50 ± 6 kg/m2 vs. CONmale 44 ± 5 kg/m2, p = 0.001. Bariatric surgery results in comparable changes in BMI in HYPOmale and CONmale − 16 ± 6 kg/m2 vs. − 14 ± 5 kg/m2, p = 0.30. Weight loss reversed hypogonadism in 93%. In women, androgen excess was present in 22%, independent of pre-operative BMI: CONfemale 44 ± 7 kg/m2 vs. HYPERfemale 45 ± 7 kg/m2, p = 0.57. Changes in BMI were comparable in HYPERfemale and CONfemale after bariatric surgery − 15 ± 6 kg/m2 vs. − 15 ± 5 kg/m2, p = 0.88. Hyperandrogenemia was reversed in 61%. Conclusions Besides being frequently observed, hypogonadism in men and androgen excess in women have no impact on post-surgical improvements in body weight and glucose and lipid metabolism. Weight loss resulted in reversal of hypogonadism in almost all men and of hyperandrogenemia in the majority of women. |
| Databáze: | OpenAIRE |
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