Parasite–Vector Interaction of Chagas Disease: A Mini-Review
| Autor: | Kaio Cesar Chaboli Alevi, Maria Tercília Vilela de Azeredo-Oliveira, Carlos Henrique Lima Imperador, Ana Beatriz Oliveira, Fernanda Fernandez Madeira |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chagas disease 030231 tropical medicine Review Article Biology Mini review 03 medical and health sciences 0302 clinical medicine Virology parasitic diseases medicine Parasite hosting Animals Humans In patient Chagas Disease Triatoma Trypanosoma cruzi Transmission (medicine) biology.organism_classification medicine.disease Insect Vectors 030104 developmental biology Infectious Diseases Vector (epidemiology) Immunology Parasitology |
| Popis: | Trypanosoma cruzi is a protozoan of great importance to public health: it has infected millions of people in the world and is the etiologic agent of Chagas disease, which can cause cardiac and gastrointestinal disorders in patients and may even lead to death. The main vector of transmission of this parasite is triatomine bugs, which have a habit of defecating while feeding on blood and passing the parasite to their own hosts through their feces. Although it has been argued that T. cruzi is not pathogenic for this vector, other studies indicate that the success of the infection depends on several molecules and factors, including the insect's intestinal microbiota, which may experience changes as a result of infection that include decreased fitness. Moreover, the effects of infection depend on the insect species, the parasite strain, and environmental conditions involved. However, the parasite-vector interaction is still underexplored. A deeper understanding of this relationship is an important tool for discovering new approaches to T. cruzi transmission and Chagas disease. |
| Databáze: | OpenAIRE |
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