Regulatory mechanisms of heme regulatory protein BACH1: a potential therapeutic target for cancer
| Autor: | G. Ravichandran, Sivasudha Thilagar, Dinesh Kumar Lakshmanan, Sivakumar Manickam, Soumi Paul, Abirami Arunachalam, Palanirajan Vijayaraj Kumar |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Leucine zipper Angiogenesis Neovascularization Physiologic Apoptosis Heme Biology Metastasis chemistry.chemical_compound Neoplasms medicine Humans Neoplasm Metastasis Transcription factor Regulation of gene expression Cell Cycle Cancer Hematology General Medicine Cell cycle medicine.disease Oxidative Stress Basic-Leucine Zipper Transcription Factors Oncology chemistry Cancer research Heme Oxygenase-1 |
| Zdroj: | Medical Oncology. 38 |
| ISSN: | 1559-131X 1357-0560 |
| Popis: | A limited number of overexpressed transcription factors are associated with cancer progression in many types of cancer. BTB and CNC homology 1 (BACH1) is the first mammalian heme-binding transcription factor that belongs to the basic region leucine zipper (bZIP) family and a member of CNC (cap 'n' collar). It forms heterodimers with the small musculoaponeurotic fibrosarcoma (MAF) proteins and stimulates or suppresses the expression of target genes under a very low intracellular heme concentration. It possesses a significant regulatory role in heme homeostasis, oxidative stress, cell cycle, apoptosis, angiogenesis, and cancer metastasis progression. This review discusses the current knowledge about how BACH1 regulates cancer metastasis in various types of cancer and other carcinogenic associated factors such as oxidative stress, cell cycle regulation, apoptosis, and angiogenesis. Overall, from the reported studies and outcomes, it could be realized that BACH1 is a potential pharmacological target for discovering new therapeutic anticancer drugs. |
| Databáze: | OpenAIRE |
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