ACTN3 R577X polymorphism related to sarcopenia and physical fitness in active older women
| Autor: | Alba Gómez-Cabello, Ignacio Ara, Susana Aznar, José A. Casajús, Sara Vila-Maldonado, M J Artiga González, Cristina Romero-Blanco |
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| Rok vydání: | 2020 |
| Předmět: |
Gerontology
Sarcopenia Physical fitness Population Physical activity 030209 endocrinology & metabolism Genetic Condition Cohort Studies 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires Genotype medicine Humans Actinin education Aged education.field_of_study 030219 obstetrics & reproductive medicine Polymorphism Genetic Anthropometry business.industry Obstetrics and Gynecology General Medicine Middle Aged medicine.disease Cross-Sectional Studies Physical Fitness Female business |
| Zdroj: | Climacteric : the journal of the International Menopause Society. 24(1) |
| ISSN: | 1473-0804 |
| Popis: | As the population is getting older, physical activity promotion becomes a good strategy to increase quality of life in the elderly; but genetic condition also plays an important role. The purpose of this study was to examine the association of the ACTN3 R577X polymorphism with physical fitness and muscle mass in physically active older women.A cross-sectional study was performed with two groups of older women who practiced physical exercise regularly. The first cohort comprised 164 women (age 69.7 ± 3.2 years) and the second cohort 131 women (age 78.5 ± 3.0 years). The main outcome measures were anthropometric measures with assessment of sarcopenia and sarcopenic obesity, self-reported physical activity EXERNET questionnaire (EEPAQ), evaluation of physical fitness (muscle strength and flexibility test), and ACTN3 genotyping.Women above 75 years old with allele R presented a higher risk of experiencing sarcopenia compared to ACTNR XX homozygous women (odds ratio 0.356, 95% confidence interval 0.139-0.915,Sarcopenia and physical fitness show differences based on the ACTN3 R577X genotype in active older women. |
| Databáze: | OpenAIRE |
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