Selenitetriglycerides—Redox-active agents
| Autor: | Grazyna Hoser, Zofia Suchocka, Zenon Jastrzebski, Iza Książek, Karolina Sitarz, Anna Flis, Piotr Suchocki, Małgorzata Sochacka, Piotr Wroczyński, Lidia Śliwka, Monika Anna Królikowska, Małgorzata Remiszewska, Elżbieta Anuszewska |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Antineoplastic Agents Mice SCID Pharmacology medicine.disease_cause Mice Selenium Prostate cancer Mice Inbred NOD LNCaP Extracellular Animals Humans Medicine Tissue Distribution Doxorubicin Cysteine Sulfhydryl Compounds Selenium Compounds Triglycerides Aged business.industry Prostatic Neoplasms General Medicine medicine.disease In vitro Oxidative Stress Liver Apoptosis Cystine Extracellular Space business Oxidation-Reduction Intracellular Oxidative stress medicine.drug |
| Zdroj: | Pharmacological Reports. 67:1-8 |
| ISSN: | 1734-1140 |
| DOI: | 10.1016/j.pharep.2014.07.017 |
| Popis: | Background Human prostate cancer (hPCa) is the most commonly diagnosed cancer in elderly men and is the second leading cause of male cancer death. Data from epidemiological, eco-environmental, nutritional prevention and clinical trials suggest that selenium Se(IV) can prevent prostate cancer. Selol, a new organic semisynthetic derivative of Se(IV), is a mixture of selenitetriglycerides. This mixture is non-toxic and non-mutagenic, and after po treatment – 56-times less toxic (in mice) than sodium selenite. It exhibits strong anti-cancer activity in vitro in many cancer cell lines and can overcome the cell resistance to doxorubicin. Selol seems a promising compound for prostate cancer therapy. Materials and methods The aim of the present study is the evaluation of Selol's influence on intracellular redox state ( E h ) of prostatic tumors and the liver in androgen-dependent hPCa-bearing mice, and extracellular redox state in serum of these mice. Results and conclusions The anticancer activity of Selol involves perturbation of the redox regulation in the androgen dependent hPCa (LNCaP) cells, but not in healthy cells. After Selol treatment, intracellular E h has increased in tumors from −223 mV to −175 mV, while in serum it has decreased (−82 mV vs −113 mV). It shows significant changes E h in the extra- and intracellular environment. The difference decreases from 141 mV to 62 mV. The changes suggest that a tumor cell was probably directed toward apoptosis. This is exemplified in a significant decrease in cancer tumor mass by approx. 17% after the three weeks of Selol administration. |
| Databáze: | OpenAIRE |
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