Correlation between spontaneous metastatic potential, platelet-aggregating activity of cell surface extracts, and cell surface sialylation in 10 metastatic-variant derivatives of a rat renal sarcoma cell line
| Autor: | Edward Pearlstein, Simon Karpatkin, Peter L. Salk, Ganesa Yogeeswaran |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Acetylgalactosamine
Platelet Aggregation Glycoconjugate Cell Cell Line Cell membrane chemistry.chemical_compound medicine Animals Platelet Neoplasm Metastasis Glycoproteins chemistry.chemical_classification Multidisciplinary Cell Membrane medicine.disease Kidney Neoplasms Rats Sialic acid medicine.anatomical_structure chemistry Biochemistry Cell culture Sialic Acids Cancer research Sarcoma Experimental Sarcoma Glycoprotein Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 77:4336-4339 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Several properties of 10 cell lines derived from the polyoma-induced PW20 Wistar-Furth rat renal sarcoma have been examined, including the ability of the tumor cells to metastasize spontaneously from subcutaneous sites in syngeneic hosts, the platelet-aggregating activity of material extracted by urea from the surface of cultured cells, the sialic acid content of the platelet-aggregating material, and the degree of sialylation of cell surface glycoconjugates in cultured cells. A correlation has been observed among all of these parameters. The results suggest a possible link between the degree of cell surface sialylation of tumor cells, their ability to aggregate platelets, and their ability to metastasize. |
| Databáze: | OpenAIRE |
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