Randomized clinical trial on acute effects of i.v. iron sucrose during haemodialysis

Autor: A. Sánchez-Ibarrola, Isabel Coma-Canella, Aitziber Echeverria, José A. Páramo, Nuria Garcia-Fernandez
Rok vydání: 2010
Předmět:
Male
Time Factors
medicine.disease_cause
Ferric Compounds
Antioxidants
Glucaric Acid
chemistry.chemical_compound
Malondialdehyde
Prospective Studies
Endothelial dysfunction
Infusions
Intravenous
Ferric Oxide
Saccharated
CD11b Antigen
Cross-Over Studies
biology
Interleukin
General Medicine
Middle Aged
Intercellular Adhesion Molecule-1
Treatment Outcome
medicine.anatomical_structure
Nephrology
Female
Inflammation Mediators
medicine.symptom
medicine.drug
medicine.medical_specialty
Endothelium
Inflammation
Iron sucrose
Von Willebrand factor
Renal Dialysis
Internal medicine
von Willebrand Factor
medicine
Humans
Aged
business.industry
Interleukin-8
medicine.disease
Acetylcysteine
Oxidative Stress
Endocrinology
chemistry
CD18 Antigens
Immunology
Hematinics
biology.protein
Endothelium
Vascular
business
Biomarkers
Oxidative stress
Zdroj: Nephrology. 15:178-183
ISSN: 1440-1797
1320-5358
DOI: 10.1111/j.1440-1797.2009.01174.x
Popis: Aim: Haemodialysis induces endothelial dysfunction by oxidation and inflammation. Intravenous iron administration during haemodialysis could worsen endothelial dysfunction. The aim of this study was to ascertain if iron produces endothelial dysfunction and the possible neutralizing effect of N-acetylcysteine when infused before iron. The oxidative and inflammatory effects of iron during haemodialysis were also assessed. Methods: Forty patients undergoing haemodialysis were studied in a randomized and cross-over design with and without N-acetylcysteine infused before iron sucrose (50 or 100 mg). Plasma Von Willebrand factor (vWF), soluble intercellular adhesion molecule-1 (sICAM-1) levels, malondialdehyde, total antioxidant capacity, CD11b/CD18 expression in monocytes, interleukin (IL)-8 in monocytes and plasma IL-8 were studied at baseline and during haemodialysis. Results: Haemodialysis produced significant (P
Databáze: OpenAIRE
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