Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors
| Autor: | Schreml, Stephan, Ackermann, Kirsten, Wallner, Susanne, Brochhausen, Christoph |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male squamous cell carcinoma Skin Neoplasms QH301-705.5 610 Medizin TRPV Cation Channels Article basal cell carcinoma melanoma Humans Biology (General) Nevus QD1-999 Aged Aged 80 and over ddc:610 integumentary system Middle Aged proton-sensitive ion channels Acid Sensing Ion Channels Gene Expression Regulation Neoplastic Chemistry Carcinoma Basal Cell Carcinoma Squamous Cell Female |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 6024, p 6024 (2021) International Journal of Molecular Sciences Volume 22 Issue 11 |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | The acid-sensing ion channels ASIC1 and ASIC2, as well as the transient receptor potential vanilloid channels TRPV1 and TRPV4, are proton-gated cation channels that can be activated by low extracellular pH (pHe), which is a hallmark of the tumor microenvironment in solid tumors. However, the role of these channels in the development of skin tumors is still unclear. In this study, we investigated the expression profiles of ASIC1, ASIC2, TRPV1 and TRPV4 in malignant melanoma (MM), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and in nevus cell nevi (NCN). We conducted immunohistochemistry using paraffin-embedded tissue samples from patients and found that most skin tumors express ASIC1/2 and TRPV1/4. Striking results were that BCCs are often negative for ASIC2, while nearly all SCCs express this marker. Epidermal MM sometimes seem to lack ASIC1 in contrast to NCN. Dermal portions of MM show strong expression of TRPV1 more frequently than dermal NCN portions. Some NCN show a decreasing ASIC1/2 expression in deeper dermal tumor tissue, while MM seem to not lose ASIC1/2 in deeper dermal portions. ASIC1, ASIC2, TRPV1 and TRPV4 in skin tumors might be involved in tumor progression, thus being potential diagnostic and therapeutic targets. |
| Databáze: | OpenAIRE |
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