Smart dual responsive nanocarriers with reactive oxygen species amplification assisted synergistic chemotherapy against prostate cancer

Autor:	Yupeng Guan, Chengyuan Xing, Tongyu Tong, Xinyi Zhang, Jun Li, Huikun Chen, Junfeng Zhu, Yang Kang, Jun Pang
Rok vydání:	2022
Předmět:	Male Prostatic Neoplasms Hydrogen Peroxide Surfaces Coatings and Films Electronic Optical and Magnetic Materials Biomaterials Drug Liberation Colloid and Surface Chemistry Cell Line Tumor Tumor Microenvironment Humans Nanoparticles Prospective Studies Reactive Oxygen Species
Zdroj:	Journal of colloid and interface science. 622
ISSN:	1095-7103
Popis:	Conventional chemotherapy efficacy is impeded by poor water solubility, inferior tissue targeting, and severe systemic toxic effect. Synergistic chemotherapy has become prominent with the stimulus-response drug delivery system (DDS) to treat solid malignancies. The most popularly employed responsive stimulus is reactive oxygen species (ROS), which is proven to primarily sensitize chemotherapy and enhance antitumor impact. In this study, we have successfully developed smart dual responsive nanocarriers with ROS self-amplification, particularly responding to disassemble under the high levels of ROS and esterase in the tumor microenvironment (TME) and to release docetaxel (DTX) efficiently. Additionally, we utilized palmitoyl ascorbate (PA) as a stabilizer by taking advantage of its amphiphilic structure. PA is also an excellent ROS generator that produces a large amount of hydrogen peroxide (H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce3a0c6af01585e12c2477f094bfe0f https://pubmed.ncbi.nlm.nih.gov/35544966 Zobrazit plný text záznamu Full Text from ScienceDirect