A randomised oral fluoride retention study comparing intra-oral kinetics of fluoride-containing dentifrices before and after dietary acid exposure
| Autor: | Charles R. Parkinson, Ritu Karwal, Marc Nehme, Gary R. Burnett, Peter Hall, Thomas C Badrock, Gavin Vaughan Thomas |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Saliva Cocamidopropyl betaine Expectorate Fluorides 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dentifrice Humans Single-Blind Method General Dentistry Dentifrices Orange juice Cross-Over Studies Chromatography 030206 dentistry Cell Biology General Medicine Fruit and Vegetable Juices 030104 developmental biology Otorhinolaryngology chemistry Intra oral Tetrasodium pyrophosphate Acids Fluoride |
| Zdroj: | Archives of Oral Biology. 119:104891 |
| ISSN: | 0003-9969 |
| DOI: | 10.1016/j.archoralbio.2020.104891 |
| Popis: | This exploratory, randomised, single-blind, crossover, study evaluated fluoride and calcium ion concentrations and pH following use of one of two 1450 ppm fluoride (NaF), 5% w/w KNOEighteen participants used their assigned dentifrice, rinsed with DI water, then expectorate was collected. Sixty min post-brushing, participants rinsed with OJ or DI water then expectorate was collected. Saliva samples were collected pre-brushing and at 1, 5, 10, 15, 30 and 60 min post-brushing and following the 60 min OJ/DI water rinse. The pH of samples was taken.Significant differences (p0.05) were found in salivary fluoride ion concentrations between test and comparator dentifrices at 30 and 60 min and following the 60 min OJ rinse, favouring the former. Significant differences were also found between test and comparator dentifrices for salivary calcium ion concentration at 1, 5 and 10 min (p0.0001), favouring the former, and between test or comparator + OJ rinse and test + water rinse (p0.005), favouring the latter. No pH differences were shown prior to OJ/water rinse. Products were generally well-tolerated.Results confirmed that acid-labile fluoride is released from the oral cavity following a dietary acid challenge and showed that formulation excipients may impact on retention of such. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect