Transbulbar B-mode sonography in multiple sclerosis without optic neuritis; clinical relevance
| Autor: | Leila Raeesmohammadi, Masoud Mehrpour, Zahra Mirzaasgari, Mohammad Hossein Abbasi, Mohammad Reza Motamed, Hamid Reza Baradaran, Parvaneh Deilami, Sara Esmaeili |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Optic nerve sheath Multiple Sclerosis Optic Neuritis Early detection Young Adult 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Humans In patient Optic neuritis Clinical significance Molecular Biology Ultrasonography Subclinical infection business.industry General Neuroscience Multiple sclerosis Optic Nerve Middle Aged medicine.disease Magnetic Resonance Imaging Cross-Sectional Studies 030104 developmental biology Optic nerve Evoked Potentials Visual Female Neurology (clinical) business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Brain Research. 1734:146723 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2020.146723 |
| Popis: | Trans bulbar B-mode sonography (TBS) is a recently proposed method but there is little known about its diagnostic accuracy in patients with multiple sclerosis without acute optic neuritis. Therefore we assessed the correlation between OND, ONSD and OND/ONSD ratio with clinical/para clinical parameters.In a comparative study, we intended to examine possible differences in optic nerve diameter (OND) and optic nerve sheath diameter (ONSD) between 60 patients with multiple sclerosis (MS) and 60 individuals as matched healthy controls.The OND, ONSD and OND/ONSD ratio in both eyes showed significantly lower amounts in patients compared to healthy controls (p 0.05). There were no correlations, between either OND or ONSD and factors including gender, age, P100 amplitude, disease duration, history of optic neuritis and number of T2 lesions in MRI (P ≥ 0.05). Expanded disability status scale (EDSS) and p100 Latency were correlated with both OND and ONSD values (P 0.05).TBS showed significantly lower amounts of OND, ONSD and OND/ONSD ratio in MS patients without current attack compared to their healthy controls indicating a subclinical axonal loss over time. It is suggested that TBS could be an applicable tool for early detection of optic nerve damages along with clinical and para-clinical findings. |
| Databáze: | OpenAIRE |
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