A Prospective Study of Inflammation Markers in Patients at Risk of Indirect Acute Lung Injury
| Autor: | A. Takala, Sten-Erik Jansson, Sirkka-Liisa Karonen, Arto Orpana, O. Takkunen, Heikki Repo, Irma Jousela, Hannu Kautiainen |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty ARDS Adolescent Critical Care animal diseases Lung injury Critical Care and Intensive Care Medicine Systemic inflammation Gastroenterology law.invention Sepsis law Internal medicine Intensive care medicine Humans Prospective Studies Aged Aged 80 and over Inflammation Respiratory Distress Syndrome Interleukin-6 business.industry Interleukin-8 Transfusion Reaction Receptors Interleukin-2 Lung Injury Middle Aged respiratory system medicine.disease Intensive care unit respiratory tract diseases Pancreatitis Immunology Emergency Medicine Acute pancreatitis Female medicine.symptom business Biomarkers |
| Zdroj: | University of Helsinki |
| ISSN: | 1073-2322 |
| DOI: | 10.1097/00024382-200204000-00002 |
| Popis: | Systemic inflammation triggered by insults like sepsis and acute pancreatitis may play a role in development of indirect acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Because little is known about the course of systemic inflammation on the days preceding diagnosis of ARDS, we prospectively monitored immune inflammatory status in 52 patients at risk and we assessed the presence of ALI and ARDS on day 7 after admission to the intensive care unit. On admission, serum interleukin (IL) 8, IL-6, and soluble IL-2 receptor concentrations were significantly higher in patients with subsequent ALI (n = 18) than in patients without ALI (n = 30). During a 4-day follow-up, IL-8 and IL-6 levels of ALI patients remained high and those of non-ALI patients decreased. None of the markers discriminated ARDS patients (n = 9) from non-ARDS ALI patients (n = 9). Among 11 patients with acute pancreatitis, ALI patients had significantly higher IL-8, IL-6, and phagocyte CD11b expression levels than did non-ALI patients, whereas among 14 patients with massive transfusion, respective findings in ALI and non-ALI patients were comparable. Results give credence to the view that systemic inflammation plays a role in development of ALI triggered by pancreatitis, but not in that by massive transfusion. This finding, if confirmed in studies with sufficient statistical power, suggests that the patients with massive transfusion do not necessarily benefit from novel biotherapies aimed at altering the course of systemic inflammation. |
| Databáze: | OpenAIRE |
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