Acquired Brain Injury-Induced Hyperphagia and Obesity, Successfully Treated With a GLP-1 Agonist
| Autor: | Nissa Blocher, Michael Ngu, Miriam Segal |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Novel Insights From the Clinic into the Development of Metabolic Disease: Case Reports Adipose Tissue Appetite and Obesity business.industry Endocrinology Diabetes and Metabolism Glp 1 agonist digestive oral and skin physiology medicine.disease Obesity Endocrinology Internal medicine medicine business Acquired brain injury AcademicSubjects/MED00250 |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| Popis: | Background: Several Glucagon-like peptides 1 (GLP-1s) were approved since 2005 for the treatment of DM & obesity. Their usefulness in other conditions is not well studied. We present two cases of hyperphagia after TBI successfully treated with GLP-1 agonists. Clinical cases: Case 1: A 54-year-old female with a history of multiple traumatic brain injuries (multiple falls and a ski accident) complained of years of insatiable hunger leading to hyperphagia and over 20 pounds weight gain. With tremendous will-power, she avoided additional weight gain by adopting a strict meal-plan and increasing her water intake (10–12 liters a day) to relieve her hunger. She sipped so much water, that her sodium remained 123 - 133 mmol/L (ref: 135–146) with dilute urine. Initial tests revealed: IGF-1 315 ng/ml (52–328), FSH 77.5 mIU/ml (23–116.3), LH 24.3 mIU/ml (14.2–52.3), prolactin 17.1 ng.ml (10–54.7), estradiol 17 ( |
| Databáze: | OpenAIRE |
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