Gastrointestinal motility and its enteric actors in mechanosensitivity: past and present
| Autor: | Bruno Mazet |
|---|---|
| Přispěvatelé: | Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Dumonceaud, Corinne |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cell physiology
Cell type Physiology Myocytes Smooth Muscle Clinical Biochemistry Motility Enteroendocrine cell Biology Mechanotransduction Cellular Models Biological 03 medical and health sciences symbols.namesake 0302 clinical medicine Physiology (medical) parasitic diseases Animals Humans Myocyte Mechanotransduction [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] 030304 developmental biology 0303 health sciences Interstitial cell of Cajal Immunology symbols population characteristics Enteric nervous system Gastrointestinal Motility Neuroscience human activities 030217 neurology & neurosurgery |
| Zdroj: | Pflügers Archiv European Journal of Physiology Pflügers Archiv European Journal of Physiology, Springer Verlag, 2014, 467 (1), pp.191-200 Pflügers Archiv European Journal of Physiology, 2014, 467 (1), pp.191-200 |
| ISSN: | 0031-6768 1432-2013 |
| Popis: | International audience; Coordinated contractions of the smooth muscle layers of the gastrointestinal (GI) tract are required to produce motor patterns that ensure normal GI motility. The crucial role of the enteric nervous system (ENS), the intrinsic ganglionated network located within the GI wall, has long been recognized in the generation of the main motor patterns. However, devising an appropriate motility requires the integration of informations emanating from the lumen of the GI tract. As already found more than half a century ago, the ability of the GI tract to respond to mechanical forces such as stretch is not restricted to neuronal mechanisms. Instead, mechanosensitivity is now recognized as a property of several non-neuronal cell types, the excitability of which is probably involved in shaping the motor patterns. This brief review gives an overview on how mechanosensitivity of different cell types in the GI tract has been established and, whenever available, on what ionic conductances are involved in mechanotransduction and their potential impact on normal GI motility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink