Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis
| Autor: | Robert Gross, Henry W. Querfurth, Julie L. Roth, Jennifer D. Davis |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
030214 geriatrics business.industry Autoimmune limbic encephalitis Cognition Case Report lcsh:RC346-429 Immune therapy 03 medical and health sciences Personality changes 0302 clinical medicine Voltage gated potassium channel complex Memory impairment Medicine Neuropsychological testing General Agricultural and Biological Sciences business Psychiatry Cognitive impairment Neuroscience lcsh:Neurology. Diseases of the nervous system 030217 neurology & neurosurgery |
| Zdroj: | Case Reports in Neurological Medicine Case Reports in Neurological Medicine, Vol 2016 (2016) |
| ISSN: | 2090-6668 |
| Popis: | Mild cognitive impairment (MCI) can be the initial manifestation of autoimmune limbic encephalitis (ALE), a disorder that at times presents a diagnostic challenge. In addition to memory impairment, clinical features that might suggest this disorder include personality changes, agitation, insomnia, alterations of consciousness, and seizures. Once recognized, ALE typically responds to treatment with immune therapies, but long-term cognitive deficits may remain. We report two cases of patients with MCI who were ultimately diagnosed with ALE with antibodies against the voltage gated potassium channel complex. Months after apparent resolution of their encephalitides, both underwent neuropsychological testing, which demonstrated persistent cognitive deficits, primarily in the domains of memory and executive function, for cases 1 and 2, respectively. A brief review of the literature is included. |
| Databáze: | OpenAIRE |
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