Construction of poliovirus intertypic recombinants by use of cDNA
| Autor: | Glynis Dunn, Glyn Stanway, Gareth D. Westrop, D.M.A. Evans, Jeffrey W. Almond, P.D. Minor, Pamela J. Hughes, G. C. Schild |
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| Rok vydání: | 1986 |
| Předmět: |
viruses
Immunology DNA Recombinant Biology Transfection Recombinant virus medicine.disease_cause Microbiology law.invention chemistry.chemical_compound law Virology Complementary DNA medicine Genetics Mutation Base Sequence Poliovirus DNA chemistry Capsid Insect Science DNA Viral Recombinant DNA Research Article |
| Zdroj: | Journal of Virology. 57:1187-1190 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.57.3.1187-1190.1986 |
| Popis: | We investigated the use of infectious cDNA for the production of poliovirus type 1-type 3 recombinants. One such recombinant virus was produced, but a second construct involving the transfer of part of the capsid protein region was not infectious. Our results suggest that the approach may prove valuable but that not all cDNA constructs will give rise to viable viruses. |
| Databáze: | OpenAIRE |
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