Ketoconazole in experimental vaginal candidosis in rats
| Autor: | T J Savage, A E Collard, O S Kinsman |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Pharmacology Vaginal candidosis Internal medicine medicine Animals Pharmacology (medical) Vaginal epithelium Candida albicans Mycosis Candidiasis Vulvovaginal Vaginitis Chemotherapy biology Estrogens medicine.disease biology.organism_classification Rats Infectious Diseases Endocrinology medicine.anatomical_structure Ketoconazole Vagina Female medicine.drug Research Article |
| Zdroj: | Antimicrobial agents and chemotherapy. 30(5) |
| ISSN: | 0066-4804 |
| Popis: | Rats in pseudoestrous were treated subcutaneously with ketoconazole at 25 mg/kg twice a day. In both uninfected and infected rats ketoconazole inhibited the cornification of the vaginal epithelium. Thus, ketoconazole, in addition to having an antifungal effect, may aid in the removal of candida by inhibiting the epithelial conditions suitable for hyphal invasion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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