Palladium(0)‐Catalyzed Intermolecular Asymmetric Cascade Dearomatization Reaction of Indoles with Propargyl Carbonate

Autor:	Shu-Li You, Lu Ding, Run-Duo Gao
Rok vydání:	2019
Předmět:	Indole test 010405 organic chemistry Organic Chemistry Enantioselective synthesis chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis 0104 chemical sciences Stereocenter Nucleophile chemistry Propargyl Chemoselectivity Palladium
Zdroj:	Chemistry – A European Journal. 25:4330-4334
ISSN:	1521-3765 0947-6539
DOI:	10.1002/chem.201900425
Popis:	An intermolecular asymmetric cascade dearomatization reaction of indole derivatives with propargyl carbonate was developed. The challenges associated with both the chemoselectivity between the carbon and nitrogen nucleophile and the enantioselective control during the formation of an all-carbon quaternary stereogenic center were well addressed by a Pd catalytic system derived from the Feringa ligand. A series of enantioenriched multiply substituted fused indolenines were provided in good yields (71-86 %) with excellent enantioselectivity (91-96 % ee) and chemoselectivity (3/4>19:1 in most cases).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7741b764ad620804d5d63c874711c5 https://doi.org/10.1002/chem.201900425 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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