[Arg8]-Vasopressin-Induced Responses on Coronary and Mesenteric Arteries of Rats with Myocardial Infarction: The Effects of V1a-and V2-Receptor Antagonists
| Autor: | Pramod R. Saxena, R. Van Veghel, Regina Schoemaker, Inge M. Lankhuizen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Receptors Vasopressin medicine.medical_specialty Vasopressin Indoles Pyrrolidines medicine.drug_class Myocardial Infarction Coronary Circulation Internal medicine Arginine vasopressin receptor 2 medicine Animals Vasoconstrictor Agents Rats Wistar Ligation Mesenteric arteries Pharmacology business.industry Benzazepines Receptor antagonist Coronary Vessels Mesenteric Arteries Rats Arginine Vasopressin Coronary arteries Endocrinology medicine.anatomical_structure medicine.symptom Cardiology and Cardiovascular Medicine business Antidiuretic Hormone Receptor Antagonists Vasoconstriction Blood vessel Artery |
| Zdroj: | Journal of Cardiovascular Pharmacology. 36:38-44 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-200007000-00005 |
| Popis: | After myocardial infarction, plasma levels of [Arg 8 ]-vasopressin rise to recover hemodynamics. The vascular responses to [Arg 8 ]-vasopressin were studied in vitro in isolated hearts and mesenteric artery segments of rats with 1-day and 3-week-old infarcts, in absence and presence of the V 1a -receptor antagonist SR-49059 and the V 2 -receptor antagonist OPC-31260. Vascular responses of coronary arteries were similar in sham and infarcted hearts. On average, coronary flow was maximally decreased by 70 ± 3% from baseline values of 11.1 ± 0.3 ml/min, with pD 2 values of 10.52 ± 0.05. In mesenteric artery segments of sham and infarcted rats, maximal contractile forces, expressed as percentage of contraction to 125 mM KCl, were similar (232 ± 23% and 239 ± 8%, respectively). However, pD 2 values from infarcted rats (9.22 ± 0.07) were significantly lower compared with sham (9.55 ± 0.07) rats. In coronary as well as mesenteric vessels, the vasoconstrictor responses, being more susceptible to SR-49059 (apparent pA 2 , between 9.12 and 9.82) than to OPC-31260 (apparent pA 2 , between 6.21 and 6.92), seemed mediated by the V 1a receptor. These data indicate that in mesenteric but not in coronary vessels, an altered responsiveness to vasopressin could be observed. Responses are mediated mainly by the V 1a receptor. |
| Databáze: | OpenAIRE |
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