Enterovirus Transmission by Secretory Autophagy

Autor:	Nihal Altan-Bonnet, Yael Mutsafi
Rok vydání:	2018
Předmět:	0301 basic medicine syntaxin 17 RNA virus Picornavirus secretory autophagy lcsh:QR1-502 Review Coxsackievirus Syntaxin 17 Virus Replication lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine Virology Extracellular Autophagy Enterovirus Infections Animals Humans Infectivity biology poliovirus enterovirus Vesicle viral transmission Autophagosomes quasispecies biology.organism_classification Cell biology 030104 developmental biology Infectious Diseases picornavirus rhinovirus Viral replication Host-Pathogen Interactions RNA Viral 030217 neurology & neurosurgery
Zdroj:	Viruses Viruses, Vol 10, Iss 3, p 139 (2018)
ISSN:	1999-4915
Popis:	Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6557772b2dd6ef693d92b2ce261343 https://pubmed.ncbi.nlm.nih.gov/29558400 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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