Development and evaluation of mesoporous montmorillonite/magnetite nanocomposites loaded with 5-Fluorouracil
| Autor: | Muhammet Davut Arpa, Ismail Musab Gulacar, Levent Özcan, Hakan Çiftçi, Bahri Ersoy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Controlled Release
Materials science 5-Fluorouracil Kinetics Cell-Culture Magnetic Mesoporous Nanocomposite 02 engineering and technology 010402 general chemistry 01 natural sciences Nanomaterials chemistry.chemical_compound Pulmonary surfactant Silica Pillared Clay General Materials Science Magnetite Nanocomposite General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Controlled release 0104 chemical sciences Montmorillonite Chemical engineering chemistry Mechanics of Materials 0210 nano-technology Mesoporous material |
| Popis: | Porous magnetic nanomaterials have attracted great attention in a variety of applications, particularly in the magnetically targeted and/or controlled release of various species. In this study, a new route was determined to prepare magnetic and mesoporous montmorillonite/magnetite nanocomposites (Mt-Mag NCs). The changes of textural properties of Mt-Mag NCs as a function of the surfactant and silica precursor composition ratios were investigated for the first time. The NCs were then investigated for loading and release performance of 5-Fluorouracil (5-Fu). The NCs, selected for 5-Fu loading and release studies, showed a high surface area about 340.8 m(2)/ g, an average pore diameter of 8.24 nm, and a magnetization saturation of 18.7 emu/g. Interesting new information was also obtained in the method of determining 5-Fu by UV and the method was slightly modified according to obtained results. In vitro release experiments revealed that the NCs showed sustained release profiles of 5-Fu lasting approximately 8 h. Release profiles of 5-Fu from NCs could be fitted by Korsmeyer-Peppas and Hixson kinetics. In vitro cytotoxic study using MCF7 and CRL-4010 cell lines showed that the NCs are good candidates to delivery 5-Fu. Afyon Kocatepe University |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|