Hepatoprotective effects of Astragalus kahiricus root extract against ethanol-induced liver apoptosis in rats
| Autor: | Asser I. Ghoneim, Mohamed M. Radwan, Ola A. Sharaf, Soad M. Toaima, Nadia A. El-Sebakhy, Rasha M. Allam, Amani E. Khalifa, Salwa M. Nofal, Dina A. Selim, Aya M. Asaad |
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| Rok vydání: | 2012 |
| Předmět: |
Apoptosis
DNA Fragmentation Pharmacology Biology Protective Agents Plant Roots Terpene Rats Sprague-Dawley chemistry.chemical_compound Drug Discovery Animals Humans Cycloastragenol Ethanol Caspase 3 Plant Extracts General Medicine Glutathione Astragalus Plant Antimicrobial Rats Complementary and alternative medicine Biochemistry chemistry Phytochemical Liver DNA fragmentation Female Chemical and Drug Induced Liver Injury |
| Zdroj: | Chinese journal of natural medicines. 11(4) |
| ISSN: | 1875-5364 |
| Popis: | The hepatoprotective activity of the ethanol extract of Astragalus kahiricus (Fabaceae) roots against ethanol-induced liver apoptosis was evaluated and it showed very promising hepatoprotective actions through different mechanisms. The extract counteracted the ethanol-induced liver enzymes leakage and glutathione depletion. In addition, it demonstrated anti-apoptotic effects against caspase-3 activation and DNA fragmentation that were confirmed by liver histopathological examination. Moreover, the phytochemical study of this extract led to the isolation of four cycloartane-type triterpenes identified as astrasieversianin II (1), astramembrannin II (2), astrasieversianin XIV (3), and cycloastragenol (4). The structures of these isolates were established by HRESI-MS and 1D and 2D NMR experiments. The antimicrobial, antimalarial, and cytotoxic activities of the isolates were further evaluated, but none of them showed any activity. |
| Databáze: | OpenAIRE |
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