Phosphorogenic and spontaneous formation of tris(bipyridine)ruthenium in peptide scaffolds
| Autor: | Seiichi Tada, Yoshihiro Ito, Marziyeh Karimiavargani, Noriko Minagawa, Yoshihiro Shimizu, Takuji Hirose, Takanori Uzawa |
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| Rok vydání: | 2018 |
| Předmět: |
Tris
chemistry.chemical_element Peptide 010402 general chemistry Electrochemistry 01 natural sciences Biochemistry Ruthenium chemistry.chemical_compound Bipyridine Structural Biology Drug Discovery Polymer chemistry Metalloprotein Organometallic Compounds Triplet state Molecular Biology Pharmacology chemistry.chemical_classification Molecular Structure 010405 organic chemistry Chemistry Organic Chemistry General Medicine Photochemical Processes 0104 chemical sciences Molecular Medicine Peptides Oxidation-Reduction Derivative (chemistry) |
| Zdroj: | Journal of peptide science : an official publication of the European Peptide Society. 25(4) |
| ISSN: | 1099-1387 |
| Popis: | Redox-active ruthenium complexes have been widely used in various fields; however, the harsh conditions required for their synthesis are not always conducive to their subsequent use in biological applications. In this study, we demonstrate the spontaneous formation of a derivative of tris(bipyridine)ruthenium at 37°C through the coordination of three bipyridyl ligands incorporated into a peptide to a ruthenium ion. Specifically, we synthesized six bipyridyl-functionalized peptides with randomly chosen sequences. The six peptides bound to ruthenium ions and exhibited similar spectroscopic and electrochemical features to tris(bipyridine)ruthenium, indicating the formation of ruthenium complexes as we anticipated. The photo-excited triplet state of the ruthenium complex formed in the peptides exhibited an approximately 1.6-fold longer lifetime than that of tris(bipyridine)ruthenium. We also found that the photo-excited state of the ruthenium complexes was able to transfer an electron to methyl viologen, indicating that the ruthenium complexes formed in the peptides had the same ability to transfer charge as tris(bipyridine)ruthenium. We believe that this strategy of producing ruthenium complexes in peptides under mild conditions will pave the way for developing new metallopeptides and metalloproteins containing functional metal-complexes. |
| Databáze: | OpenAIRE |
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