Does physical training increase insulin sensitivity in chronic heart failure patients?
| Autor: | W. L. Mosterd, L W.E. Sabelis, M. L. Zonderland, P J. Senden, H. J. Hulzebos, T. W. Van Haeften, A. van de Wiel, B. C. M. Te Boekhorst |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG |
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty HOMEOSTASIS Heart disease EXERCISE GLUCOSE Algemeen onderzoek physical training Other medical specialities Oxygen Consumption Insulin resistance Internal medicine MUSCLES medicine euglycaemic clamp Humans Insulin insulin sensitivity Geneeskunde(GENK) Aged Heart Failure Econometric and Statistical Methods: General Exercise Tolerance Ejection fraction business.industry VO2 max ENDURANCE MEN General Medicine Middle Aged Glucose clamp technique Anthropometry medicine.disease General [Econometric and Statistical Methods] DYSFUNCTION Exercise Therapy chronic heart failure Endocrinology Heart failure randomized controlled trial Body Composition Glucose Clamp Technique Cardiology Female Insulin Resistance business Body mass index RESISTANCE |
| Zdroj: | Clinical Science, 106(5), 459. Portland Press Ltd. Clinical Science, 106(5), 459-466. PORTLAND PRESS LTD |
| ISSN: | 0143-5221 |
| Popis: | To determine the effect of training on insulin sensitivity (IS) and how this relates to peak 02 (peak oxygen uptake) in CHF (chronic heart failure), 77 CHF patients (New York Heart Association class, II/III; men/women, 59/18; age, 60 +/- 9 years; body mass index, 26.7 +/- 3.9 kg/m(2); left ventricular ejection fraction, 26.9 +/- 8.1%; expressed as means +/- S.D.) participated in the study. Patients were randomly assigned to a training or control group (TrG or CG respectively). Sixty-one patients completed the study. Patients participated in training (combined strength and endurance exercises) four times per week, two times supervised and two times at home. Before and after intervention, anthropometry, IS (euglycaemic hyperinsulinaemic clamp) and peak 02 (incremental cycle ergometry) were assessed. Intervention did not affect IS significantly, even though IS increased by 20% in TrG and 11% in CG (not significant). Peak (V)over dot O-2 increased as a result of training (6% increase in TrG; 2% decrease in CG; P |
| Databáze: | OpenAIRE |
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