Circular RNAs in stem cells: from basic research to clinical implications
| Autor: | Hui-Juan Lu, Juan Li, Guodong Yang, Cun-Jian Yi, Daping Zhang, Fenggang Yu, Zhaowu Ma |
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| Rok vydání: | 2021 |
| Předmět: |
Genotype
Molecular Interactions Stem Cells Biophysics Cell Differentiation Cell Biology RNA Circular Biochemistry Molecular Bases of Health & Disease Translational Research Biomedical regulatory mechanisms clinical implication stemness Phenotype Gene Expression Regulation Neoplasms Neoplastic Stem Cells Animals Humans RNA Molecular Biology Review Articles Biomarkers Stem Cell Transplantation circular RNAs |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 |
| Popis: | Circular RNAs (circRNAs) are a special class of endogenous RNAs with a wide variety of pathophysiological functions via diverse mechanisms, including transcription, microRNA (miRNA) sponge, protein sponge/decoy, and translation. Stem cells are pluripotent cells with unique properties of self-renewal and differentiation. Dysregulated circRNAs identified in various stem cell types can affect stem cell self-renewal and differentiation potential by manipulating stemness. However, the emerging roles of circRNAs in stem cells remain largely unknown. This review summarizes the major functions and mechanisms of action of circRNAs in stem cell biology and disease progression. We also highlight circRNA-mediated common pathways in diverse stem cell types and discuss their diagnostic significance with respect to stem cell-based therapy. |
| Databáze: | OpenAIRE |
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